A sore appears in the first, or primary, stage. Sometimes, more than one sore appears. The time between infection with syphilis and the appearance of the sore can range from 10 to 90 days (average time is three weeks).
The sore is usually firm, round, small, and painless. It appears at the spot where the infection entered your body. In women this can include the vulva, vagina, cervix, anus, rectum, tongue, lips, or other parts of the body.2
In this stage, syphilis can be passed to others through contact with the sore during vaginal, oral, or anal sex. The sore usually lasts three to six weeks and heals on its own. But if the syphilis infection is not treated, it moves to the second stage.