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Syphilis fact sheet

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Syphilis (SIF-uh-luhss) is a sexually transmitted infection (STI). It is spread by vaginal, oral, or anal sex. A pregnant woman can also spread syphilis to her baby. Syphilis is easy to treat with medicine in the early stages. But without treatment, syphilis progresses to a late stage and can damage your body's organs, leading to severe illness and even death.

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What is syphilis?

Syphilis is an STI caused by bacteria.

Who gets syphilis?

Syphilis is more common in men than women. In 2013, of the more than 17,000 people in the United States diagnosed in the first or second stage of syphilis, about 1,500 were women.1 But, women with syphilis who are pregnant are at high risk for passing syphilis to their unborn babies. Untreated syphilis can cause stillbirth (babies who are born dead) or infant death soon after birth.

How do you get syphilis?

Syphilis is spread:

  • Through direct contact with a syphilis sore or rash during vaginal, oral, or anal sex. Sores can be on or in the external genitals, vagina, anus, or rectum. They can also be on the lips or tongue or other parts of the body.
  • From a mother to her baby during pregnancy, childbirth, or breastfeeding

What are the different stages of syphilis?

Syphilis has four stages:

  1. Primary stage
  2. Secondary stage
  3. Inactive (latent) stage
  4. Late (tertiary) stage

Each stage of syphilis has different symptoms. A person with syphilis can pass it to others during the primary and secondary stages.

What happens during the first (primary) stage of syphilis?

A sore appears in the first, or primary, stage. Sometimes, more than one sore appears. The time between infection with syphilis and the appearance of the sore can range from 10 to 90 days (average time is three weeks).

The sore is usually firm, round, small, and painless. It appears at the spot where the infection entered your body. In women this can include the vulva, vagina, cervix, anus, rectum, tongue, lips, or other parts of the body.2

In this stage, syphilis can be passed to others through contact with the sore during vaginal, oral, or anal sex. The sore usually lasts three to six weeks and heals on its own. But if the syphilis infection is not treated, it moves to the second stage.

What happens during the second (secondary) stage of syphilis?

The second stage can start as the sore is healing or up to several weeks after it has healed. It usually starts with a rash on one or more areas of the body.

Some or all of these signs or symptoms can appear:

  • Skin rash with rough, red, or reddish-brown spots. The rash may appear on your stomach, chest, palms, or bottoms of your feet. The rash usually does not itch.
  • Sores on the throat, mouth, or cervix
  • Fever
  • Swollen glands
  • Patchy hair loss
  • Headaches and muscle aches
  • Weight loss
  • Tiredness

In this stage, the infection can be passed to others through contact with open sores during vaginal, oral, or anal sex. The rash and other symptoms will go away on their own. But without treatment, the syphilis infection will move to the latent and possibly late stages of disease.

What happens during the inactive (latent) stage of syphilis?

The inactive, or latent, stage of syphilis starts when symptoms from the first and second stages go away. The latent stage can last for many years. During this stage, the infection lives in your body even though you have no signs or symptoms.

You cannot pass syphilis to anyone else during the latent stage. But during the first year of latency, symptoms of the second stage (such as the rash or sore) may return in some women. If you have sores, you can infect others.

Without treatment, the infection may advance to the late stage.

What happens during the late (tertiary) stage of syphilis?

About 15% of people with untreated syphilis will advance to the late stage.3 This can happen 10 to 20 years after a person first becomes infected.

In the late stage, the disease can hurt your organs, including the brain, nerves, eyes, heart, blood vessels, liver, bones, and joints. This damage can lead to nerve problems, paralysis, blindness, deafness, dementia, and other health problems. Late-stage syphilis can lead to death.

You will only reach the late stage of syphilis if you do not receive treatment earlier.

Do I need to get tested for syphilis?

Ask your doctor or nurse about getting tested for syphilis if:

  • You have signs or symptoms of syphilis
  • You think you might have been exposed to someone with syphilis
  • You have been diagnosed with another STI, including HIV
  • You are pregnant. All pregnant women need to be tested for syphilis at their first checkup. Some pregnant women need to be tested again, later in the pregnancy. Ask your doctor or nurse about retesting.
  • Your or your partner's sexual behavior puts you at risk for STIs (having sex with multiple partners, having unprotected sex, or having sex with men who have sex with men). Ask your doctor or nurse how often you should be retested.

How is syphilis diagnosed?

There are two ways that a doctor or nurse tests for syphilis:

  • Taking a sample of your blood and sending it to a lab for testing
  • Looking at fluid from a syphilis sore under a special type of microscope (this can only be done when you can see a sore)

A Pap test is not used to detect syphilis.

How is syphilis treated?

Penicillin (an antibiotic) is the best medicine to treat syphilis at all stages. How much penicillin you have to take and how long you have to take it for depend on the stage of syphilis and your symptoms. One dose of penicillin is usually enough to treat people who have had syphilis for less than one year. If you are in a later stage of syphilis, you may need more medicine.

Do not have sex until the syphilis sores are completely gone. Your sex partners need to be tested. If they have syphilis, they will need to take penicillin.

Syphilis can be cured if it is found early and treated. Syphilis can damage the heart or brain if it is not treated in the early stages. Syphilis can be cured in the later stages, but it may not be possible to fix the damage done to the heart or brain.

What if I have an allergy to medicine used to treat syphilis?

The medicine used to treat syphilis is penicillin. If you are allergic to penicillin, other medicines might work during the early stages of syphilis.

You cannot take these other medicines during pregnancy. If you are pregnant and allergic to penicillin, your doctor will work with you to help you become less sensitive to the penicillin before you are treated with it.

In late syphilis, penicillin will prevent further harm, but it cannot fix any permanent damage already done to internal organs.

What can happen if syphilis is not treated?

Without treatment, syphilis can lead to severe illness and even death.

Having syphilis also raises your risk of getting or giving HIV, the virus that causes AIDS. The open sores caused by syphilis make it easier for HIV to spread through sexual contact. If you have a syphilis sore, you are two to five times more likely to get HIV if exposed through sex.4

How does syphilis affect pregnancy?

Pregnant women can pass syphilis to their babies during pregnancy or birth. Syphilis can cause miscarriage, stillbirth, or the baby's death soon after birth. Untreated syphilis in pregnant women results in infant death in up to 40% of cases.3

Babies born to mothers who have syphilis may not have signs or symptoms of syphilis at birth. But if not treated right away, the baby may develop serious problems within a few weeks. These include:

  • Skin sores and rashes
  • Fever
  • Jaundice
  • Anemia
  • Swollen liver and spleen

Untreated syphilis in babies can cause developmental delays, seizures, or death.

How is syphilis treated during pregnancy?

The U.S. Preventive Services Task Force recommends that all pregnant women be tested for syphilis.5 Pregnant women with syphilis need to be treated right away with penicillin. For women who are allergic to penicillin, no other medicines are available for treatment. Your doctor will help you become less sensitive to the penicillin so it can be used before your baby is born.

Treatment with penicillin will prevent passing syphilis to the baby. But women who are treated during the second half of pregnancy are at risk of premature labor and problems with their unborn baby.

Can I breastfeed if I have syphilis?

Yes, you can breastfeed if you have syphilis, but not if you have a sore on one or both of your breasts. If you have syphilis, it is possible to spread the infection to any part of your breast, including your nipple and areola. You can then spread syphilis to your baby.

If you have any syphilis sores on one or both of your breasts:

  • You can keep breastfeeding as long as your baby or pumping equipment does not touch a sore.
  • Pump or hand-express your milk from the breast with sores until the sores heal. Pumping will help keep up your milk supply and prevent your breast from getting overly full and painful. You can store your milk to give to your baby in a bottle for another feeding. But if parts of your breast pump also touch the sore(s) while pumping, throw the milk away.

What should I do if I have syphilis?

Syphilis can be treated. But you need to be tested and treated as soon as possible.

If you have syphilis:

  • See a doctor or nurse as soon as possible. Penicillin will treat syphilis, but it will not fix any permanent damage done to your internal organs.
  • Take all of your medicine. Even if the symptoms go away, you still need to finish all of the penicillin. If symptoms continue after treatment, see your doctor or nurse.
  • Tell your sex partner(s) so they can be tested and treated. If they are not tested and treated you could get syphilis again.
  • Avoid any sexual activity while you are being treated for syphilis. Don't have sexual contact until the syphilis sores are completely healed.
  • After you have completed treatment for syphilis, get retested after 6 months and 12 months. Your doctor or nurse may recommend more frequent follow-up tests.
  • Get tested for HIV. If your test result is negative, ask your doctor or nurse if you need to be retested and when.

How can I prevent syphilis?

The best way to prevent syphilis or any STI is to not have vaginal, oral, or anal sex.

If you do have sex, lower your risk of getting an STI with the following steps:

  • Use condoms. Condoms are the best way to prevent STIs when you have sex. Because a man does not need to ejaculate (come) to spread syphilis, make sure to put the condom on before the penis touches the vagina, mouth, or anus. Also, other methods of birth control, like birth control pills, shots, implants, or diaphragms, will not protect you from STIs.
  • Get tested. Be sure you and your partner are tested for STIs. Talk to each other about your test results before you have sex.
  • Be monogamous. Having sex with just one partner can lower your risk for STIs. After being tested for STIs, be faithful to each other. That means that you have sex only with each other and no one else.
  • Limit your number of sex partners. Your risk of getting STIs goes up with the number of partners you have.
  • Do not douche. Douching removes some of the normal bacteria in the vagina, and may increase your risk of getting STIs.
  • Do not abuse alcohol or drugs. Drinking too much alcohol or using drugs increases risky behavior and may put you at risk of sexual assault and possible exposure to STIs.

The steps work best when used together. No single step can protect you from every single type of STI.

Can women who have sex with women get syphilis?

Yes. It is possible to get syphilis, or any other STI, if you are a woman who has sex only with women.

Talk to your partner about her sexual history before having sex, and ask your doctor or nurse about getting tested if you have signs or symptoms of syphilis. Use a dental dam during oral sex and avoid sexual activity during an outbreak.

Do you need more information about syphilis?

For more information about syphilis, call the OWH Helpline at 800-994-9662 or contact the following organizations:


  1. Centers for Disease Control and Prevention. (2014). 2013 Sexually Transmitted Disease Surveillance. Table 1 and Table 28.
  2. Chandra, A., Mosher, W. D., Copen, C., & Sionean, C. (2011). Sexual behavior, sexual attraction, and sexual identity in the United States: Data from the 2006–2008 National Survey of Family Growth. National Health Statistics Report, 3(36), 1–36.
  3. Centers for Disease Control and Prevention. (2015). Syphilis - CDC Fact Sheet.
  4. Centers for Disease Control and Prevention. (1998). HIV prevention through early detection and treatment of other sexually transmitted diseases—United States. Recommendations of the Advisory Committee for HIV and STD prevention. MMWR Recommendations and Reports, 47(RR–12), 1–24.
  5. U.S. Preventive Services Task Force. (2009). Screening for Syphilis Infection in Pregnancy.

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All material contained on this page is free of copyright restrictions and may be copied, reproduced, or duplicated without permission of the Office on Women's Health in the Department of Health and Human Services. Citation of the source is appreciated.

This fact sheet was reviewed by Centers for Disease Control and Prevention (CDC) staff.

Content last updated: August 31, 2015.

Content last reviewed: March 25, 2014.

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